Cytokine profile during occult hepatitis B virus infection in chronic hepatitis C patients

Abstract Background The hepatitis B virus (HBV) is one of the leading causes acute, chronic and occult (OBI) representing a serious public health threat. Cytokines are known to be important chemical mediators that regulate differentiation, proliferation function immune cells. Accumulating evidence indicate inadequate responses responsible for HBV persistency. aim this study were investigate cytokines IFN-?, TNF-?, IL-2, IL-4, IL-6, IL-10 IL-17A in patients with OBI verify if there an association between levels these determination clinical courses during infection. Methods 114 C investigated through serological molecular tests, coinfected subjected test using commercial human CBA kit. As controls, ten healthy donors no history liver disease 10 monoinfected similar age selected. Results Among HCV investigated, 11 individuals had B. heterogeneous groups, most showed higher production detection among OBI/HCV when compared control group pacients. We found high level group, IL-10, IL-4 IL-2 patients. Conclusion These could involved persistence DNA hepatocytes triggers constant response, inducing continuous inflammation, which can accelerate damage favor development cirrhosis other diseases.